Glial cell line-derived neurotrophic factor protects astrocytes from staurosporine- and ischemia- induced apoptosis
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Glial cell line-derived neurotrophic factor protects astrocytes from staurosporine- and ischemia- induced apoptosis.
Glial cell line-derived neurotrophic factor (GDNF) promotes the survival and functions of neurons. It has been shown to be a promising candidate in the treatment of ischemia and other neurodegenerative diseases. We transfected mouse astrocytes in primary cultures with a human GDNF gene and found that their conditioned medium could not only support the growth and survival of cultured dopaminergi...
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ژورنال
عنوان ژورنال: Journal of Neuroscience Research
سال: 2007
ISSN: 0360-4012,1097-4547
DOI: 10.1002/jnr.21345